Incretin Effect of Glucagon-Like Peptide 1 Receptor Agonist Is Preserved in Presence of ABCC8/SUR1 Mutation in -Cell
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منابع مشابه
Incretin Effect of Glucagon-Like Peptide 1 Receptor Agonist Is Preserved in Presence of ABCC8/SUR1 Mutation in β-Cell
ABCC8/SUR1-activating mutations induce neonatal diabetes (1) or other diabetes (1–4). Sulfonylurea treatment is unsuccessful in 15% patients (2,3). Glucagon-like peptide 1 (GLP-1) enhances insulin secretion by activating diverse signaling pathways (4). This study aimed at exploring if the GLP-1 effect is retained when b-cell dysfunction is related to ABCC8 mutation. Three informed patients were...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2012
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc12-0535